The Seelbach Hilton is a historic hotel in Louisville, Kentucky, founded by Bavarian-born immigrant brothers Louis and Otto Seelbach. It opened in 1905 as the Seelbach Hotel, envisioned by the Seelbach Brothers to embody the old-world grandeur of European hotels in cities such as Vienna and Paris. To do so in early 20th century Louisville, they employed a French Renaissance design in constructing the hotel. Louis was already a restaurant owner in Louisville when his brother Otto joined him from Germany around 1890, forming the Seelbach Hotel Co. The Company began construction on the hotel in 1903.

The hotel was quickly regarded among the finest hotels in the United States and throughout its long history has been frequented by many notable Americans — for instance F. Scott Fitzgerald, who took inspiration from the Seelbach for a hotel in The Great Gatsby. The hotel is part of the Hilton Hotels & Resorts chain.

The Seelbach has a resident ghost known as “The Lady in Blue”.